Detalhe da pesquisa
1.
Molecular mechanisms of PI4K regulation and their involvement in viral replication.
Traffic
; 24(3): 131-145, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35579216
2.
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.
J Am Chem Soc
; 144(14): 6326-6342, 2022 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35353516
3.
Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.
EMBO Rep
; 21(2): e48441, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31829496
4.
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nature
; 538(7625): 344-349, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27602946
5.
Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.
Adv Exp Med Biol
; 1274: 203-222, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32894512
6.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
7.
Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease.
Biochem Soc Trans
; 44(1): 260-6, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26862213
8.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
9.
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Sci Adv
; 9(46): eadi7359, 2023 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37967183
10.
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.
ACS Infect Dis
; 6(11): 3048-3063, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32966036
11.
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase.
J Med Chem
; 62(13): 6241-6261, 2019 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31244112
12.
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.
Nat Commun
; 9(1): 3772, 2018 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217979
13.
The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIß, PI4KB, through ACBD3.
Structure
; 25(1): 121-131, 2017 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27989622
14.
Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIß with Rab11.
Protein Sci
; 25(4): 826-39, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26756197
15.
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIß.
J Med Chem
; 59(5): 1830-9, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26885694